7 FAQs For PRP (Platelet Rich Plasma) Tubes

1. What Is the Difference Between PRP, PRF, and CGF?

PRP (Platelet Rich Plasma), PRF (Platelet Rich Fibrin), and CGF (Concentrated Growth Factors) are all platelet-derived therapies, but they have key differences:

• PRP (Platelet Rich Plasma): The most widely used term, PRP involves centrifuging blood to concentrate platelets, then activating them with thrombin.
• PRF (Platelet Rich Fibrin): Developed to avoid animal-derived thrombin, PRF uses a single centrifugation process without anticoagulants, forming a natural fibrin gel with better structural stability.
• CGF (Concentrated Growth Factors): Popular in aesthetics, CGF is derived from PRP and contains a higher concentration of growth factors.

2. Why Do People Confuse PRP and PRF?

The confusion arises because PRF was introduced as a thrombin-free alternative to PRP. Since thrombin (used in PRP) can have potential side effects, PRF offers a safer, more natural clotting process.

3. How Is PRF Prepared Differently from PRP?

• PRP: Requires anticoagulants and thrombin activation.
• PRF: Only needs one centrifugation—no additives. Blood clots naturally, forming a fibrin-rich gel with superior mechanical properties.

4. What Are the Advantages of PRF Over PRP?

• No exogenous additives (safer).
• Single centrifugation (simpler process).
• Stronger fibrin structure (better tissue support).

5. Is CGF Just a Marketing Term?

CGF is an evolution of PRP, focusing on higher growth factor concentrations. While it’s widely used in cosmetics, its biological components are similar to PRP.

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6. Why Is PRF Considered Safer Than PRP?

PRF eliminates the need for:
✔️ Animal-derived thrombin (reducing allergy risks)
✔️ Anticoagulants (simpler process)
✔️ Multiple centrifugations (gentler on platelets)

7. How Is PRF Prepared Differently from PRP?